Since 2019, scientists and experienced proofreaders have utilized FlyWire to proofread AI segmentation of a full fly brain (Dorkenwald et al., Zheng et al.). As of October, 2022, over 80,000 neurons have been proofread in FlyWire, including the entire central brain.
Automatically extracted presynaptic and postsynaptic tags have been applied to all putative connections in the brain (Buhmann et al.), and the dominant neurotransmitter assigned for most neurons (Eckstein et al.).
Explore networks using neuron IDs in the FlyWire Codex (FlyWire signup required). Further analysis tools are forthcoming. For programmatic analysis, see natverse (R) and CAVE (Python).
Community of neurobiologists, computer scientists, and proofreaders who build and curate the first whole brain connectome for Drosophila in FlyWire. Join FlyWire and contribute community data for your lab to appear.
Members adhere to a set of shared principles to join the community: FlyWire Data and Principles.
FlyWire is created by the labs of Mala Murthy and Sebastian Seung at Princeton University. It is funded by the US Brain Initiative. Proofreading and annotation has been carried out in collaboration with the Cambridge Drosophila Connectomics Group (funded by the Wellcome trust) and many other labs around the world.
Central Brain Proofreading Completion
Optic Lobes Proofreading Completion
Overall Proofreading Completion
Some cool 3D renderings
Scientific publications derived in whole or in part from use of FlyWire should cite FlyWire: online community for whole brain connectomics. Dorkenwald et al. Nature Methods 2022, and should acknowledge the Princeton FlyWire team and members of the Murthy and Seung labs for development and maintenance of FlyWire (supported by BRAIN Initiative grant MH117815 to Murthy and Seung).
To use neurons proofread of labeled by the community, see this document.